This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie COFUND grant agreement No 665735.

Bio4Med Research Projects:


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3: Bio4Med - The role of Arc protein in the regulation of alcohol addiction-related behaviors

Supervisor:
prof. Katarzyna Radwanska
Foreign partner:
Dr Hiroyuki Okuno, Medical Innovation Center, Kyoto University Graduate School of Medicine, Japan
WWW
http://en.nencki.gov.pl/laboratory-of-molecular-basis-of-behavior
Background:
Arc is an immediate-early gene involved in the regulation of synaptic plasticity. Arc expression was shown to be activated both by drugs of abuse and exposure to drug-paired context. The role of Arc in the regulation of addiction-related behaviors is however still unknown. In the current project we would like to focus on the role of Arc protein in the regulation of alcohol addiction.
Aim:
The specific aims of the project are: 1. To establish the role of Arc protein in the regulation of alcohol addiction-related behaviors. 2. To characterize Arc expression pattern in animal model of alcohol addiction. 3. Molecular characteristics of Arc-positive neurons in alcohol addiction. 4. To establish the role of Arc-positive neurons in alcohol withdrawal. In the current project we would like to use Arc KO mice, and other Arc-specific molecular interventions in mice, in order to investigate the role of Arc in the regulation of alcohol addiction. Candidates must not have resided or carried out their main activity (work, studies, etc.) in Poland for more than 12 months in the past 3 years.
Requirements:
We invite applicants with a strong background in neuroscience, biology or engineering who are keen to understand how the brain changes in response to alcohol.