This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie COFUND grant agreement No 665735.

Bio4Med Research Projects:

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12: Bio4Med - Cortical network reorganization following focal retinal damage

prof. Wioletta Waleszczyk
Foreign partner:
Prof. Zoltan Kisvar Kisarday, University of Debrecen, Debrecen, Hungary
Disturbances in sensory information input to the cortex results in massive reorganization of cortical neuronal network. In particular, functional and structural network reorganization in the visual cortex occurs during diseases of the visual system, such as retinal detachment, glaucoma, retinal changes in diabetes, age dependent macular degeneration, in which reduced visual information reaches the cortex. Elucidation of the neuronal mechanisms underlying network reorganization is essential for the understanding impairment of visual perception and for development of therapies of visual dysfunctions in these disorders.
The aim of the project is to examine functional changes of sensory processing and to describe structural reorganization of the cortical neuronal circuits after disturbance of sensory input. In particular, the research will aim to answer the question, how local cooperation between neurons changes following retinal damage leading to topographic reorganization of the visual field representation in the visual cortex. The study will be performed on animals using in vivo electrophysiology, optical imaging, optogenetic tools, anatomical methods, and off-line signal analysis.
Medical degree or MSc degree with a background in biology, psychology or physics. Strong motivation for scientific work, independence, creative approach to problem solving, and ability to work in a team. Proficiency in English. Familiarity with experiments on animals, histological, optical imaging or electrophysiological methods and signal analysis would be a plus. Candidates must not have resided or carried out their main activity (work, studies, etc.) in Poland for more than 12 months in the past 3 years.