This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie COFUND grant agreement No 665735.

Bio4Med Research Projects:


<<< back to list

13: Bio4Med - Novel regulators of cilia motility

Supervisor:
prof. Dorota Wloga
Foreign partner:
Prof. Jarema Malicki, University of Sheffield, UK; Prof.Gaia Pigino, Max Planck Institute, Dresden
WWW
http://www.nencki.gov.pl/en/laboratory-of-physiology-of-cell-movements
Background:
Our main scientific interest is focused on cilia assembly and motility regulation. Cilia are highly specialized, evolutionary conserved microtubule-based organelles that play essential sensory and locomotory roles. In multicellular organisms, the coordinated beating of numerous motile cilia assembled by the epithelial cells lining the internal tracks, propels fluids or cells along surface of epithelia. In humans, lack or dysfunction of motile cilia leads to a heterogenic group of disorders called primary ciliary dyskinesia (PCD), a syndrome diagnosed in 1:15 000 births that manifests by chronic respiratory problems, male and female infertility, inverted internal organs and sometimes hydrocephalus. The genetic background of the substantial portion of the recognized PCD cases remains unknown.
Aim:
The main aim of the proposed project is to identify new ciliary proteins engaged in cilia motility regulation using multiple parallel model systems (ciliate Tetrahymena thermophila, mammalian cells and zebrafish embryos) and advanced molecular, biochemical and imaging approaches in Nencki Institute in co-operation with researches from two distinguished partner institutions: University of Sheffield (United Kingdom, laboratory of Prof. Jarema Malicki) and Max Planck Institute (Germany, laboratory of Dr. Gaia Pigino).
Requirements:
We are seeking highly motivated, passionate candidates with strong academic record and general experience in laboratory work. Skills in cell culture, microscopy and molecular biology are expected; good communication and English language skills are essential as well as a willingness to work flexibly and travel to collaborating partners.