This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie COFUND grant agreement No 665735.

Bio4Med Research Projects:


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6: Bio4Med - Mitochondrial physiology in cells derived from patients with neurodegenerative diseases, in particular: familial form of Parkinson Disease

Supervisor:
prof. Jerzy Duszyński
Foreign partner:
National Ukrainian Academy of Sciences
WWW
www.duszynskilab.nencki.gov.pl
Background:
Our laboratory has a long and extensive expertise in mitochondrial studies. Most of the methods relevant to mitochondrial physiology are currently available for my team. We have adequate instruments for these studies. On top of this, the Nencki Institute has very advanced general facilities devoted to, for example, biological imaging or sequencing. Defects in mitochondrial function have been implicated in a wide array of human diseases, spanning from specific genetic defects to neurodegenerative diseases. While mitochondrial dysfunction is evident in neurodegeneration, its precise role in disease progression is unclear and the mechanisms of its origin is not well understood. For our research, Parkinson familiar model disease, in which mitochondrial dysfunction has been found, will be investigated. Particular attention will be focused on finding the elements implicated in mitochondria – nuclear crosstalk and mechanisms of its regulation.
Aim:
To determine the mitochondrial physiology mostly influenced by mutations leading to neurodegenerative disease and to find the metabolic state of the cell that this modification is especially significant.
Requirements:
Motivated and gifted experimentalist, fluent English